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Acknowledgment The authors would like to express their sincere gratitude and thanks to Student Research Committee of Isfahan University of Medical Sciences for funding this study, carried out as a research project (No

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1 (1) CD013229

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The consensus report by the National Academy of Sciences, Engineering, and Medicine concluded that [t]here is conclusive evidence that completely substituting e-cigarettes for combustible tobacco cigarettes reduces users exposure to numerous toxicants and carcinogens present in combustible tobacco cigarettes (National Academies 2018)