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They claimed that their products caused no adverse side-effects, with the apparent backing of medical specialists. This advert claimed to prevent throat irritation and coughing. It was considered uncouth for a woman to smoke at the turn of the 20th century, but as the Prohibition era came to an end, tobacco companies aggressively targeted the untapped female market

Therefore, the gut microbiota has the possibility to affect smoking though the pathways of microbiota-gut-brain-smoking and on the contrary gut microbial homeostasis could be a potential target for addressing tobacco use via improving brain functions [29]

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