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The guidance specifically recommends healthcare professionals routinely coming into contact with pregnant smokers: Ask: Identify pregnant smokers by assessing/documenting/discussing exposure to tobacco smoke and conducting an expired-air carbon monoxide test

"Further studies will be required to investigate whether these features could be used to individually predict cancer in smokers and e-cigarette users." The study describes how over 3,500 samples of body cells were tested for the epigenetic effects of tobacco and e-cigarettes on DNA methylation