Studies have shown that long non-coding RNA (lncRNA), microRNA (miRNA) and DNA methylation, through various mechanisms to regulate the transcription of genes and proteins, and activate a series of molecular signal pathways to participate in the process of apoptosis [44,45,46](Table 1)
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Given the demographic nuances between the results of the online and household, it is recommended to consider the following minimum attributes for any plain packaging proposal in the Philippines: (a) the graphic health warning occupying 85% of the top sections of both the front and back of the pack, (b) brand name and variant limited to the lower bottom of the pack, (c) pack color in Pantone 448C, (d) rotating graphic health warnings with pilot testing before issuance, (e) visible text health warning on at least 60% of the sides of the pack, and