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Importantly, this study showed that in early tumourigenesis PM2.5 exposure in mice with pre-existing EGFR mutation promotes transcriptional reprogramming of AT2 cells to a state that is reminiscent of a progenitor cell [121]

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Though it was difficult to make a large profit on manufactured tobacco due to the high federal revenue tax placed on it during this period, the Duke's country enterprise continued to grow steadily in the late 1860s as the market for Duke's tobacco expanded and subsequent peddling journeys were launched from the homestead