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Both innate and adaptive immune cells can take on a senescence-associated secretory phenotype (SASP), a key feature of aged cells, noted by a modified secretory profile that includes a high level of inflammatory cytokines, growth factors and metalloproteinases including IL-6, TNF, and growth/differentiation factor 15 (GDF15), cytokines increasingly recognized as central mediators of age-related inflammatory disease processes (3840)