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Chronic use disrupts GABA and glutamate, causing tolerance and withdrawal symptoms when not drinking Cognitive impacts: memory loss, attention difficulties, impaired problem-solvingsometimes persisting 1-2 years into sobriety Depression, anxiety, and suicidality risk increases 2-3x with alcohol misuse Wernicke-Korsakoff syndromea thiamine deficiency causing confusion, poor coordination, and severe memory problemsaffects 10-30% of dependent drinkers Some brain damage reverses with sustained sobriety

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[66] Solo band members [edit] Guitar Steve Vai (19861989) Bass guitar Billy Sheehan (19861988) Percussion Gregg Bissonette (19861992) Band member timeline [edit] Guitar [edit] Al Estrada - lead guitar (2019present) [67] Jake Faun - rhythm guitar (2020) Frankie Lindia - rhythm guitar (2020) Brian Young - lead guitar (20022006) Toshi Hiketa - rhythm guitar (20032006) Bart Walsh (19992001) (died 2019) Mike Hartman (1998) (died 2000) John 5 (1998, 2012, 2019) Steve Hunter (19901992, 1997) Terry Kilgore (19931994) Rocket Ritchotte (19931994) Joe Holmes (19911992) Desi Rexx (1991, a few shows in Europe only) [68] Jason Becker (19901991) Steve Vai (19851989) Bass guitar [edit] Ryan Wheeler (20202026) Todd Jensen (19901991, 19992000, 20042006) James LoMenzo (20012004) B'urbon Bob (1998)pseudonym for John 5 John Regan (1994) James Hunting (19931994) Matt Bissonette (19881990) Billy Sheehan (19851988) Drums [edit] Francis Valentino (2020present) Mike Musselman (20192020) Jimmy DeGrasso (2006) Ray Luzier (19972000, 20012005) Ron Wikso (19931994) Larry Aberman (1994) Joseph Hudson (19931994, 19951997) Gregg Bissonette (19851992) Keyboard [edit] Danny Wagner (20202025) [nb 1] Marcus Margand II (20002001) Patrick Howard I (19981999) Billy Thompson (19961998) Richard Hilton (19941995) Brett Tuggle (19881994, 1997) (died 2022) Jesse Harms (1986) Discography [edit] Studio albums [edit] Eat 'Em and Smile (1986) Skyscraper (1988) A Little Ain't Enough (1991) Your Filthy Little Mouth (1994) DLR Band (1998) Diamond Dave (2003) Extended plays [edit] Crazy from the Heat (1985) with Van Halen [edit] Van Halen (1978) Van Halen II (1979) Women and Children First (1980) Fair Warning (1981) Diver Down (1982) 1984 (1984) A Different Kind of Truth (2012) Books [edit] Crazy from the Heat