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Combined Venetoclax and Ibrutinib for Patients with Previously Untreated High-Risk CLL, and Relapsed/Refractory CLL: A Phase II Trial

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As between-study heterogeneity can be underestimated or even zero when the number of studies is small 196,197 , we used Fishers information matrix to estimate the uncertainty of the heterogeneity 198 and incorporated that uncertainty into the final results