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The limbs and neck are the most commonly affected sites, but other areas of skin and mucosa may be involved Morphologically the lesions can be vesicles, bullae, plaques, nodules, and erosions / ulcers Other neutophilic dermatoses, eg pyoderma gangrenosum , can also occasionally cause blistering Refer to the chapter Neutrophilic dermatoses Lymphomatoid papulosis (figure 64) Is characterised by recurrent crops of pruritic papules at different stages of development that predominantly arise on the trunk and limbs Each erythematous papule evolves into a red-brown, often haemorrhagic, papulovesicular or papulopustular lesion over days to weeks

The tendency to only increase when levels are below average may also be the case during aging, where efficient mitochondrial function is reduced

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