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Cannabis is usually smoked in cigarettes called "joints" or in pipes

Not everyone with a genetic profile associated with RA will develop the disease, and while not all environmental factors are known, smoking tobacco has been consistently identified as a major contributor to the risk of developing RA that is associated with elevated levels of anticyclic citrullinated peptide (anti-CCP), which in turn is associated with more aggressive disease and severe joint erosion (5)

Nicotine's effects are intense but short-lived, and surges of dopamine teach the brain to seek out unhealthy stimuli to get the feel-good chemical fix again and again

Understanding nicotine isn't just about identifying its sources but grasping its deep-rooted impact on our culture, physiology, and, as we'll soon discover, our mental health