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Also, even though several prescription-only, as well as over-the-counter, nicotine replacement products were available to smokers during this time period, not enough smokers used nicotine replacement therapy (NRT) when trying to quit and, consequently, the availability of NRT has not had a significant effect on population-level prevalence of smoking over the years 50

10.1136/tobaccocontrol-2018-054372 46

Similarly, the limited number of studies conducted in long-term sole users of e-cigarettes have been completed in regional cohorts, where environmental factors, as well as the laws and restrictions on e-cigarette products, can vary

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The enrolled participants were divided into two group viz., 1)