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Gilbert and colleagues [18] tested 42 male smokers who were randomly assigned to nicotine, placebo, or wait-list conditions

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However, perhaps even more so than with the evidence base regarding e-cigarettes, the risks posed by Tobacco Heating Products are as yet not well characterised and placing such products on a continuum of risk is again largely a matter of educated conjecture based on toxicant emissions, toxicant exposure, and biological testing data

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