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However, nicotine and toxic combustion products are readily absorbed through the oral mucosa and upper airways, leading to systemic CV effects

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Progress was initially notable at a state or national level, particularly the pioneering smoke-free public places legislation introduced in New York City in 2002 and the Republic of Ireland in 2004, and the UK efforts to encapsulate the crucial elements of tobacco control activity in the 2004 'six-strand approach' (to deliver upon the joined-up approach set out in the white paper 'Smoking Kills' [16] ) and its local equivalent, the 'seven hexagons of tobacco control'