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This results in a chronic localized irritation

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After nicotine administration, impaired and diminished clearance of LDL and accelerated lipid transfer from HDL increases their deposition in the arterial wall, which result in the atherogenic lipid profile (increased LDL, decreased HDL/total cholesterol ratio) [276, 277]

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The report stressed that evidence has linked smoking to diseases of nearly all organs of the body and that smoking costs more than 289 billion US dollars a year in direct medical care and other economic costs.