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[9] Tobacco was introduced elsewhere in continental Europe more easily

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Nicotine withdrawal symptoms include cravings, anxiety, irritability, and insomnia, peaking within the first three days and subsiding in 4-6 weeks

Elevated rates of ischemic heart disease, stroke and endocarditis suggest the cardiotoxic impact of drugs, with cocaine linked to ischemia and stroke and methamphetamine associated with cardiomyopathy and pulmonary hypertension