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Moreover, MMP12 knockout (KO) mice have been shown to exhibit (1) decrease emphysema symptoms, marked by a reduction of pulmonary inflammation [33], as well as (2) reduction in allergen-induced exacerbations [34], highlighting key influential roles for MMP12 in emphysema and asthma pathogenesis, respectively

This suggests that the state has not done enough to discourage new smokers from joining the legions of the nations smokers

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