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Cray, the lead author of the work, noted that because propylene gylcol had been linked to an increased uptake of nicotine, a lot of companies have moved toward getting away from a high percentage of propylene glycol toward more glycerol, trying to position this as a safer alternative. The researchers had believed that heavier propylene glycol should be causing more effects but he said it was the exact opposite. The results were consistent across several litters of mice in both biological sexes