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Hoarseness in patients with no obvious precipitating cause exceeding a fortnight should be referred on for specialist investigation

Inflammation and cancer Many cancers arise in areas of chronic inflammation, which plays a major role in tumor invasion, progression, and metastasis, largely through the cytokine-mediated activation of mechanisms involved in tissue repair, cell proliferation and angiogenesis [20, 22, 51,52,53]

Nicotine pouches contain refined nicotine powder, additives, humectants, pH stabilizers, and flavors, which are safer than the ingredients of the alternatives.

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