smokeless tobacco mouth and Oral Health Mouth Cancer From Chewing Tobacco:

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The primary enzyme responsible for metabolising nicotine is designated P450 (CYP) 2A6, and studies show genetic differences that cause variations in this enzyme from person to person - and these differences can affect the speed at which nicotine is broken down by up to half

Substantial evidence indicates that exposure to household air pollution, particularly from indoor sources such as biomass cooking fuel, firewood heating, and candles [16], is also associated with an increased risk of developing COPD [17], especially in low- and middle-income countries [18] where children and women are predominantly exposed [19]

Health Place 2020

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