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Prior cigarette smokers had rolled their own, which tended to obscure the potential for a national market for a pre-packaged product

The evidence for combined interventions was primarily from behavioural interventions combined with NRT or bupropion, but the results likely also apply to varenicline70 and may also apply to cytisine, in the judgment of the task force

A PRISMA diagram detailing the systematic review approach, a description of the studies included and the full details about the methods are in Supplementary Information 1.5 and 5.2

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