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The chemical constituents or main ingredients present in the smokeless tobacco products are nicotine, tobacco-specific N-nitrosamines (TSNA), nitrosamine acids, polycyclic aromatic hydrocarbons (PAHs), aldehydes, and heavy metals 4

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This may reflect the difference in the proportion of ever-smokers (50.3% in our study, 72.6% in their study), since KRAS G12C was found to be more strongly associated with smoking-associated signature four in lung adenocarcinoma than other KRAS mutations.29 To explain why pack-years was superior to smoking duration in predicting the frequencies of KRAS mutations, we divided KRAS subtypes (G12A, G12C, G12D, G12V) into four groups according to smoking duration and pack-years

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