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All authors contributed to the article and approved the submitted version

Details on each study includedi.e., study design, number of participants, exposure and outcome definitions, and confounders adjusted forcan be found in the Supplementary Information

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Drawing upon the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted three systematic reviews to capture all available peer-reviewed literature pertaining to chewing tobacco and five types of head and neck cancers, ischemic heart disease, and stroke