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Funding The author(s) declared that financial support was not received for this work and/or its publication

In 1492, Rodrigo de Jerez scouted Cuba for Christopher Columbus and was the first European to experience tobacco smoking

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The recall was as the result of identifying an issue with manufacturing equipment during routine inspection that caused metal-to-metal abrasion

Details on each study includedi.e., study design, number of participants, exposure and outcome definitions, and confounders adjusted forcan be found in the Supplementary Information