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10.1136/thoraxjnl-2016-208964 143 NgM

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The National Health Plan (NHP) 1998-2000 includes tobacco control as one of its main objectives, implemented through specific actions, including national, regional and local measures, health education interventions for students and pregnant women, and the monitoring of the correct application of existing legislation

FA and VB 12 deficiencies also reduce DNA methylation via homocysteine increase, ultimately aggravating the effect of air pollution on DNA methylation (81)