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The average 5-year survival rate has remained practically unchanged over the last 40 years: at 7583% for patients with localized HNSCC, 4565% for those whose cancer spread to regional lymph nodes, and only 3340% for those with distant metastasis 2
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Enhancer of zester homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PCR2), and its-terminal SET domain exhibits methyl transferase activity 9
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