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Oral Cancer : Tobacco is a significant risk factor that can lead to epigenetic modifications of oral epithelial cells, impair various systemic immune functions of the host, and its toxic metabolites can induce oxidative stress in tissues

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Once triggered, NLRP3 drives the production of pro-inflammatory cytokines including IL-1 and IL-18 and elevates C-reactive protein (CRP), a primary biomarker of systemic inflammation and a direct participant in atherosclerosis formation