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Differences in clinical and radiographic appearances may be due to a variety of factors, such as underlying lung disease, individual variations in host responses to the inhaled substance, and the specific material inhaled, which is often difficult to determine

Copenhagen Tobacco's original fine cut snuff contains 12.7 mg of nicotine per gram, which is 2 to 3 times the standard amount

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This is not a zero-risk option, but a documented order-of-magnitude difference in respiratory burden

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