judy garland smoking 80 cigarettes a day The Experience™: I Could Go On Singing (right after this cigarette) TIL while filming The Wizard

Nicotine from a smoked cigarette will reach the brain in as little as 7 seconds after inhalation. The addictive effect of nicotine is linked to its capacity to trigger the release of dopamine a chemical in the brain that is associated with feelings of pleasure

Over time, this desynchronization compounds fatigue by preventing proper recovery during sleep hours

- 23% LOAP FUKSIE, TM

For the sake of simplicity, lets assume that one vape puff is equal to one drag of a cigarette as mentioned, this is what you can expect from a modern device containing 5% nicotine

They are involved in immune responses and the secretion of inflammatory cytokines