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INH is a prodrug that enters the Mtb cytoplasm via passive diffusion, where it inhibits mycolic acid synthesis by targeting the InhA enzyme, an essential catalyst in an early step of the mycolic acid biosynthetic pathway (Mitchison, 1956)

The authors acknowledge the assistance provided by the staff of Anthonio Research Center, Ekpoma, Edo State, Nigeria, for their unconditional help during the experimental stage of this study

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