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Conversely, concomitant use of nicotine and rifabutin, a CYP2B6 inducer, will result in a modest increase in mediated metabolism of the substrate, potentially leading to a reduction in serum concentration and/or therapeutic effect (DrugBank Clinical API Plugins, 2024)

(3) is being used by nicotine-nave individuals, especially children

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Although these abnormalities are not specific, their coexistence highlights the complexity of CRP and the importance of a comprehensive systemic evaluation