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In other autoimmune conditions, like rheumatoid arthritis, we know that smoking is a risk factor, but this has not been previously studied in AAV in a robust way. A poor understanding of risk factors limits our ability to provide recommendations on how to reduce ones risk of AAV and the general counseling we provide patients with AAV, he added

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The Cochrane Tobacco Addiction Group's research prioritization exercise involved more than 300 people and identified a total of 183 unanswered questions in tobacco control through two online surveys and an Oxford-based workshop

Allina J, Grabowski J, Doherty-Lyons S, Fiel MI, Jackson CE, Zelikoff JT et al (2011) Maternal allergy acts synergistically with cigarette smoke exposure during pregnancy to induce hepatic fibrosis in adult male offspring