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doi:10.3389/fddsv.2023.1082058 "Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency"

13 Based on a 2013 systematic review that pooled 26 trials (n = 22,239), rates of smoking cessation at 6 months or more were an average of 8.0% in groups that received physician advice compared with 4.8% in groups that received no advice or usual care (risk ratio [RR], 1.76 [95% CI, 1.58-1.96])

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10.1 Consistency over time Smokers who value: Stable draw Even burn Minimal variation often choose hard packs

Gradual Reduction: Slowly decreasing the amount of smoking according to a set plan that you stick tosuitable for heavy smokers