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The growth of common Streptococcus species, in particular Streptococcus intermedius , Streptococcus anguinis , and Streptococcus mutans from saliva are shown to be suppressed by prolonged exposure to the aqueous extracts of betel nut such as tannic acid ( Streptococcus anginosus , is shown to induce the synthesis of inflammatory cytokines and NO (Sasaki et al., 2001) signifying potential mechanisms of carcinogenesis

The disruption of the stop signals can be caused by genetic, or inherited, defects in the cells DNA , or by external dangers such as radiation or environmental toxins, such as pollutants or chemicals, both of which can cause damage to the cells DNA

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9 Robusto or My Father Le Bijou 1922