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We did not adjust our main analysis for smoking-related diseases, because in theory, these variables were mediators of the causal pathway from cigarette smoke exposure to poorer HRQOL

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Furthermore, in vitro and in vivo studies allow for the measurement of the relative expression levels of genes involved in the DDR machinery and provide the means to further confirm that a cMRTP aerosol causes less DNA damage than cigarette smoke in exposed tissues [40, 41, 46]

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