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Nicotine Withdrawal in the Vicious Cycle of Addiction A "circulus vitiosus" also called a vicious or downward spiral is seen as a barrier in addiction that makes tobacco cessation difficult for many, fueling ongoing consumption

8.1 Pharmacological interventions targeting mitochondria Mitochondrial dysfunction plays a significant role in various inflammatory lung diseases, including asthma, COPD, and pulmonary fibrosis