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[3] In 1561 Jean Nicot, the French ambassador in Lisbon, Portugal, who described tobacco's medicinal properties as a panacea in his writings, is credited with introducing ground tobacco snuff to the Royal Court of Catherine de' Medici to treat her persistent headaches

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Recent studies have shown that the brain may have a much weaker neuro-immune response to systemic infection and inflammation, though no differences to baseline immune activation were found

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