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The hives occur at the site of contact with the allergen or irritating substance, up to 1 hour after the exposure

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However, e-cigarettes contain many of the same chemicals as cigarettes

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Thus, chronic exposure to cigarette smoke causes persistent inflammation and oxidative stress in the lungs, leading to repeated repair and remodeling (leading to airway remodeling), stimulating mucus hypersecretion (leading to chronic bronchitis), and degrading the alveolar walls (leading to emphysema) (Fig