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Figures Abstract Cigarette smoke contains numerous toxicants, including cadmium, polycyclic aromatic hydrocarbons (PAHs), tobacco-specific nitrosamines (TSNAs), and volatile organic compounds, all of which may contribute to hepato-renal injury

Inclusion criteria In this research review, the focus was primarily on observational studies, which include cohort, case-control, and cross-sectional methodologies, as well as intervention studies, encompassing both randomized controlled and experimental designs

Children are at particular risk

This innovation meets the rising demand for reduced-risk tobacco alternatives, offering enhanced aerosol delivery, flavor retention, and filtration efficiency

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