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1) Shortness of breath because of problems with the lungs, such as: Blood clot Swelling and mucus buildup Chronic obstructive pulmonary disease (COPD) Pneumonia High blood pressure Other lung disease 2) Problems with the airways that lead to the lungs, which may cause shortness of breath: Air passages in your nose, mouth, or throat are blocked Choking because of something that is stuck in the airways Swelling around the vocal cords Asthma 3) Shortness of breath because of problems with the heart that may include: Chest pain because of poor blood flow through the hearts blood vessels Heart attack Heart defects from birth Heart failure Heart rhythm disturbance 4) Other causes for shortness of breath may include: Allergies High altitudes where there is less oxygen in the air Dust in the environment Emotional distress, like anxiety Panic attacks What can cause shortness of breath at night