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In the CHRIS Studys examination, CHRIS participants were requested to spit 5 milliliters of saliva into a special collection tube

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Also, several researches suggested that fear emotions may play an important role in the effectiveness of the pictorial warning ads and helping in message acceptance, thinking about the health risks and helping to quit from the dangerous addiction [1,15,16]

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Two key factors that play a role in the gateway drug hypothesis are drug-class specificity and the influence of sex and early drug exposure