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When he left the confines of the small screen for big-screen pastures, Clooney transcended mere stardom to become one of the most prominent actors of his era, emulating the devil-may-care nonchalance of a Cary Grant or Clark Gable, while at the same time becoming an Academy Award-winning performer, risk-taking director, and socially-conscious activist

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Additionally, the reacquisition of more developmentally primitive transcriptional gene programs has been observed in metastasis of both mouse and human lung adenocarcinoma [53]