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To further confirm this chain of causal inference, we implemented a modified Mendelian randomisation (MR) analysis to investigate potential causal effects by introducing non-pleiotropic polygenic risk scores (PRS) as instrument variables, i.e., the valid-PRS (see Methods for more details) 35,36

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The most common hazards that come as a result of smoking while driving include: Distracted or reckless driving Burns from cigarette butts falling while driving Inability to see the road when trying to light a cigarette Inability or unwillingness to use both hands to drive while holding a cigarette with one hand Potential fire hazards Cognitive distraction, or when the persons mind is on other things besides driving Increased time of distraction (cigarette smokers have an average of 12 seconds of distraction, whereas those using their cellphones have an average of 10.6 seconds of distraction) As you can see, the primary concern with smoking and driving is the distractibility of the driver