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Exposure to tobacco smoke not only have both direct and indirect effects on the health of human but also affects all stages of human reproduction and development [33].Tobacco contains more than 4000 compounds, out of which at least 70 compounds have been identified as carcinogenic [15].According to statistics, approximately 46% of men aged 2039 years smoke, and the actual use of cigarettes increased from 721 million cigarettes in 1980 to 967 million cigarettes in 2012 [34]

Unfortunately, the variety of products available as well as the ongoing modifications of e-cigarette and vaping devices makes it difficult to comprehensively evaluate the biological risk of vaping and specific e-liquids (29)

Empirical studies promote the use of evidence or logic reasoning before approaching a certain decision

38 , 37375 (IARC, Lyon, 1986)

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