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[3] It has been shown that aphthous stomatitis is more common in people using toothpastes containing SLS, and that some reduction in ulceration occurs when an SLS-free toothpaste is used

Interaction 2 Nicotine Speeds Caffeine Clearance Smokers metabolise caffeine twice as fast as non-smokers Nicotine induces liver enzymes (CYP1A2) that significantly accelerate caffeine metabolism smokers clear caffeine from their system approximately twice as fast as non-smokers