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Civil rights and social justice groups such as the American Civil Liberties Union align with law enforcement organizations, libertarians and conservatives in criticizing the bid to enact one of the most significant prohibitions in decades

Food and Drug Administration (FDA) and Director of the FDAs Center for Tobacco Products wrote in 2017: Nicotine, though not benign, is not directly responsible for the tobacco-caused cancer, lung disease, and heart disease that kill hundreds of thousands of Americans each year . Tobacco smoke contains more than 6,000 chemicals, nearly 100 of which have been classified by public health agencies as harmful or potentially harmful constituents

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