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49), Bob Fitzsimmons (No

2010, Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. This neurotransmitter release results in feelings of pleasure and reward, reinforcing the addictive nature of tobacco use

In 2026, 1.4% of current vapers who vape with nicotine said they use nicotine strengths above the legal limit, and 17% did not know what strength they used

This size is less typical and is frequently employed for marketing or convenience.

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