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The PP6C decrease in smoke exposed males is consistent with apoptotic loss of tracheal mucosal epithelium at the 75 mg TPM/m 3 dose and may reflect apoptosis associated remodeling as part of the reparative hyperplasia seen at 200 and 400 mg TPM/m 3

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Nicotine interacts with the phrenic nerve, which helps control the diaphragm

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