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Notably, fractional exhaled nitric oxide (FENO) - a marker of inflammation in the airways - showed a statistically significant decrease after HTP use

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Although, re-challenge/provocation tests, intradermal tests or skin prick tests are of significant value in identifying the culprit drug, they are time consuming, need expertise or may even re-precipitate life-threatening adverse drug reaction that may raise ethical issues

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Then, due to the proximity that macrophages and tumor cells reside in, interactions between VCAM-1 and the 4 integrins are promoted, which recruit Ezrin, a cytoplasmic adaptor protein that links the actin cytoskeleton to the cytoplasmic tail of VCAM-1, and ultimately results in tyrosine phosphorylation of Ezrin