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Its not hard to see a metaphor here, with the doomed creatures representing smokers trapped and enslaved by Big Tobacco

2017;14:641-651.[PubMed Abstract] - 22.Grebely J, Dalgard O, Conway B, et al

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We used 353 independent single-nucleotide polymorphisms associated with cigarette smoking initiation as instrumental variables at genome-wide significance threshold ( p 0.1), leaving 353 independent instrumental variables for smoking initiation

When assigning codes from Chapter 15, it is important to assess if a condition was pre-existing prior to pregnancy or developed during or due to the pregnancy in order to assign the correct code