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Until 2024, no flavored e-cigarette device had received an FDA marketing order and only 23 unflavored (tobacco-flavored) vapes received approval

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In monitored short-term human exposure reports, unequivocal connections between exposure and inflammation have been found less reliably, likely owing to variation in research procedures, participant susceptibility, or previous unmeasured exposures (3)

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The role of nicotine in the effects of maternal smoking during pregnancy on lung development and childhood respiratory disease